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Regen Med. 2016 Dec;11(8):767-775. Epub 2016 Nov 25.

Regenerative Medicine: lessons from Mother Nature.

Author information

1
McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15219, USA.
2
Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.
3
Division of Pediatric Pulmonary Medicine, Allergy & Immunology, Children's Hospital of UPMC, Pittsburgh, PA 15224, USA.
4
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Abstract

Regenerative medicine strategies for the restoration of functional tissue have evolved from the concept of ex vivo creation of engineered tissue toward the broader concept of in vivo induction of functional tissue reconstruction. Multidisciplinary approaches are being investigated to achieve this goal using evolutionarily conserved principles of stem cell biology, developmental biology and immunology, current methods of engineering and medicine. This evolution from ex vivo tissue engineering to the manipulation of fundamental in vivo tenets of development and regeneration has the potential to capitalize upon the incredibly complex and only partially understood ability of cells to adapt, proliferate, self-organize and differentiate into functional tissue.

KEYWORDS:

bioscaffolds; blastema; constructive remodeling; development; microenvironmental niche; regeneration; stem cell; tissue engineering; whole-organ engineering

PMID:
27885899
PMCID:
PMC6439514
DOI:
10.2217/rme-2016-0111
[Indexed for MEDLINE]
Free PMC Article

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