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Methods Mol Biol. 2017;1512:171-188.

Mouse Models for Campylobacter jejuni Colonization and Infection.

Author information

1
Division of Gastroenterology, Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, V6H 3V4, Canada.
2
Division of Gastroenterology, Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, V6H 3V4, Canada. bvallance@cw.bc.ca.

Abstract

Relevant animal models for Campylobacter jejuni infection have been difficult to establish due to C. jejuni's inability to cause disease in many common animal research models. Fortunately, recent work has proven successful in developing several new and relevant mouse models of C. jejuni infection, including the SIGIRR-deficient mouse strain that develops acute enterocolitis in response to C. jejuni. Here we describe how to properly infect mice with C. jejuni, as well as a number of accompanying histological techniques to aid in studying C. jejuni colonization and infection in mice.

KEYWORDS:

Campylobacter jejuni; Histology; Immunofluorescence; Mouse models; Pathology; Staining

PMID:
27885607
DOI:
10.1007/978-1-4939-6536-6_15
[Indexed for MEDLINE]

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