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Occup Environ Med. 2017 Jan;74(1):66-71. doi: 10.1136/oemed-2016-103678. Epub 2016 Nov 24.

CONSTANCES: a general prospective population-based cohort for occupational and environmental epidemiology: cohort profile.

Author information

1
Population-based Epidemiological Cohorts Unit, INSERM UMS 11, Villejuif, France.
2
Paris Descartes University, Paris, France.
3
Occupational Health Unit, Raymond Poincaré Hospital, Garches, France.
4
LEEST, Medical School, Angers University, Angers, France.

Abstract

WHY THE COHORT WAS SET UP?: CONSTANCES is a general-purpose cohort with a focus on occupational and environmental factors.

COHORT PARTICIPANTS:

CONSTANCES was designed as a randomly selected sample of French adults aged 18-69 years at inception; 200 000 participants will be included.

DATA COLLECTION PHASES:

At enrolment, the participants are invited to complete questionnaires and to attend a health screening centre (HSC) for a health examination. A biobank will be set up. The follow-up includes an yearly self-administered questionnaire, a periodic visit to an HSC and linkage to social and national health administrative databases.

MAIN TYPES OF DATA COLLECTED:

Data collected for participants include social and demographic characteristics, socioeconomic status, life events and behaviours. Regarding occupational and environmental factors, a wealth of data on organisational, chemical, biological, biomechanical and psychosocial lifelong exposure, as well as residential characteristics, are collected at enrolment and during follow-up. The health data cover a wide spectrum: self-reported health scales, reported prevalent and incident diseases, long-term chronic diseases and hospitalisations, sick-leaves, handicaps, limitations, disabilities and injuries, healthcare usage and services provided, and causes of death.

CONTROL OF SELECTION EFFECTS:

To take into account non-participation and attrition, a random cohort of non-participants was set up and will be followed through the same national databases as participants.

DATA ACCESS:

Inclusions begun at the end of 2012 and more than 110 000 participants were already included by September 2016. Several projects on occupational and environmental risks already applied to a public call for nested research projects.

KEYWORDS:

Aging; Chronic diseases; Occupational epidemiology; Population-based cohort

PMID:
27884936
PMCID:
PMC5241503
DOI:
10.1136/oemed-2016-103678
[Indexed for MEDLINE]
Free PMC Article

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