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Epilepsia. 2017 Mar;58(3):315-330. doi: 10.1111/epi.13621. Epub 2016 Nov 24.

WONOEP appraisal: Imaging biomarkers in epilepsy.

Author information

1
Department of (Neuro)Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
2
Department of Translational Neurosciences, University of Antwerp, Wilrijk, Belgium.
3
Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, U.S.A.
4
Department of Brain and Cognitive Sciences, Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer Sheva, Israel.
5
Department of Medical Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada.
6
Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, United Kingdom.
7
Institute of Pharmacology, Toxicology and Pharmacy, Ludwig-Maximilian-University, Munich, Germany.
8
Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
9
Departments of Clinical Neurosciences and Radiology, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.

Abstract

Neuroimaging offers a wide range of opportunities to obtain information about neuronal activity, brain inflammation, blood-brain barrier alterations, and various molecular alterations during epileptogenesis or for the prediction of pharmacoresponsiveness as well as postoperative outcome. Imaging biomarkers were examined during the XIII Workshop on Neurobiology of Epilepsy (XIII WONOEP) organized in 2015 by the Neurobiology Commission of the International League Against Epilepsy (ILAE). Here we present an extended summary of the discussed issues and provide an overview of the current state of knowledge regarding the biomarker potential of different neuroimaging approaches for epilepsy.

KEYWORDS:

Biomarker; Blood-brain barrier; Epileptogenesis; Imaging; Inflammation; Traumatic brain injury

PMID:
27883181
DOI:
10.1111/epi.13621
[Indexed for MEDLINE]
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