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Osteoporos Int. 2017 Apr;28(4):1265-1269. doi: 10.1007/s00198-016-3842-x. Epub 2016 Nov 24.

Impact of attention deficit hyperactivity disorder therapy on fracture risk in children treated in German pediatric practices.

Author information

1
Faculty of Medicine, University of Paris 5, Paris, France.
2
Department of Epidemiology, IMS Health, Darmstädter Landstraße 108, 60598, Frankfurt am Main, Germany. kkostev@de.imshealth.com.

Abstract

Two thousand eight hundred ninety-four children and adolescents treated by 243 pediatricians were analyzed. Patients receiving attention deficit hyperactivity disorder (ADHD) medications were at a lower risk of fractures than patients without ADHD medications. The strongest impact was in the age group of 6-9 years. Finally, there was a significant association between therapy duration and fracture risk.

INTRODUCTION:

The aim of this study was to analyze the impact of ADHD therapy on fracture risk in children treated by German pediatricians.

METHODS:

Children and adolescents initially diagnosed with ADHD and fractures between 2010 and 2015 were identified by 243 pediatricians. In this nested case-control study, each ADHD case with a fracture was matched (1:1) to an ADHD control without a fracture for age, gender, index year, and physician. In total, 2894 individuals were available for analysis. The main outcome of the study was the risk of fracture as a function of ADHD therapy. Multivariate logistic regression models were created to determine the effect of ADHD therapy on the risk of fracture in the entire population and in three age-specific subgroups.

RESULTS:

Patients receiving ADHD medications were at a lower risk of fracture than patients without ADHD medications (OR = 0.61). The impact of ADHD therapy on the risk of fracture was stronger in the age group of 6-9 years (OR = 0.41) than in the age groups of 10-13 years (OR = 0.68) and 14-17 years (OR = 0.74). Finally, a significant correlation was found between therapy duration and fracture risk (OR = 0.71 per month).

CONCLUSION:

ADHD therapy was associated with a decrease in the risk of fracture in children and adolescents treated by German pediatricians.

KEYWORDS:

Attention deficit hyperactivity disorder; Children and adolescents; Fracture risk; Germany

PMID:
27882412
DOI:
10.1007/s00198-016-3842-x
[Indexed for MEDLINE]

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