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Exp Ther Med. 2016 Nov;12(5):3359-3362. Epub 2016 Oct 3.

Insulin-induced autoimmune syndrome: A case report.

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Department of Endocrinology, Ningbo First Hospital, Ningbo University, Ningbo, Zhejiang 315000, P.R. China.
School of Medicine, Ningbo University, Ningbo, Zhejiang 315000, P.R. China.


Insulin autoimmune syndrome (IAS) is a disease characterized by hyperinsulinemic hypoglycemia associated with autoantibodies against endogenous insulin. A 56-year-old man was admitted to Ningbo First Hospital for the treatment of spontaneous hypoglycemia. He was found to have elevated fasting insulin level (>1,000 mIU/l) and presence of insulin autoantibodies, and after appropriate workup, was diagnosed with IAS. After treating with prednisone for 2 months, his insulin level started decreasing. In patients with repeated hypoglycemia, IAS should be considered in the differential diagnosis. Prednisone may be effective for the treatment of hypoglycemia in patients with IAS.


continuous glucose monitoring system; insulin autoantibodies; insulin autoimmune syndrome

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