Format

Send to

Choose Destination
J Pain Res. 2016 Nov 11;9:1031-1038. eCollection 2016.

Appearance of fetal pain could be associated with maturation of the mesodiencephalic structures.

Author information

1
Department of Neurology, Faculty of Medicine Novi Sad, University of Novi Sad.
2
Department of Obstetrics and Gynecology, Faculty of Medicine Novi Sad, University of Novi Sad.
3
Department of Histology and Embryology, Faculty of Medicine Novi Sad, University of Novi Sad.
4
Department of Developmental Neurology and Epilepsy, Institute for Child and Youth Health Care of Vojvodina, Faculty of Medicine Novi Sad, University of Novi Sad, Novi Sad, Serbia.
5
School of Applied Psychology, Institute Humans in Complex Systems, Olten, Switzerland.
6
Department of Orthopaedics and Traumatology, University Hospital of Heraklion, Faculty of Medicine, University of Crete, Heraklion, Greece.

Abstract

Fetal pain remains a controversial subject both in terms of recognizing its existence and the time-frame within which it appears. This article investigates the hypothesis that pain perception during development is not related to any determined structures of the central nervous system (CNS), on the contrary, the process of perception could be made with any structure satisfying conditions that the perception of pain is the organization, identification, and interpretation of sensory information in order to represent and understand the environment. According to this definition, chronic decerebrate and decorticate experimental animals, anencephalic, and hydranencephalic patients demonstrate that the basic, most general, appropriate interaction with the environment can be achieved with a functional mesodiencephalon (brain stem, and diencephalon) as the hierarchically highest structure of the CNS during development. In intact fetuses, this structure shows signs of sufficient maturation starting from the 15th week of gestation. Bearing in mind the dominant role of the reticular formation of the brain stem, which is marked by a wide divergence of afferent information, a sense of pain transmitted through it is diffuse and can dominate the overall perception of the fetus. The threshold for tactile stimuli is lower at earlier stages of gestation. The pain inhibition mechanisms are not sufficiently developed during intrauterine development, which is another factor that leads to increased intensity of pain in the fetus. As a conclusion it could be proposed that the fetus is exposed to rudimentary painful stimuli starting from the 15th gestation week and that it is extremely sensitive to painful stimuli.

KEYWORDS:

brain stem; fetus; pain; perception; thalamus

Conflict of interest statement

The authors report no conflicts of interest in this work.

Publication type

Publication type

Supplemental Content

Full text links

Icon for Dove Medical Press Icon for PubMed Central
Loading ...
Support Center