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Cell. 2016 Nov 3;167(4):933-946.e20. doi: 10.1016/j.cell.2016.09.055. Epub 2016 Oct 27.

The Serotonergic System Tracks the Outcomes of Actions to Mediate Short-Term Motor Learning.

Author information

1
Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA.
2
Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA. Electronic address: ahrensm@janelia.hhmi.org.

Abstract

To execute accurate movements, animals must continuously adapt their behavior to changes in theirĀ bodies and environments. Animals can learn changes in the relationship between their locomotor commands and the resulting distance moved, then adjust command strength to achieve a desired travel distance. It is largely unknown which circuits implement this form of motor learning, or how. Using whole-brain neuronal imaging and circuit manipulations in larval zebrafish, we discovered that the serotonergic dorsal raphe nucleus (DRN) mediates short-term locomotor learning. Serotonergic DRN neurons respond phasically to swim-induced visual motion, but little to motion that is not self-generated. During prolonged exposure to a given motosensory gain, persistent DRN activity emerges that stores the learned efficacy of motor commands and adapts future locomotor drive for tens of seconds. The DRN's ability to track the effectiveness of motor intent may constitute a computational building blockĀ for the broader functions of the serotonergic system. VIDEO ABSTRACT.

KEYWORDS:

dorsal raphe nucleus; imaging; motor learning; neural circuits; neuromodulation; neuroscience; serotonergic system; serotonin; short-term memory; zebrafish

PMID:
27881303
DOI:
10.1016/j.cell.2016.09.055
[Indexed for MEDLINE]
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