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World J Microbiol Biotechnol. 2017 Jan;33(1):11. Epub 2016 Nov 23.

The combination of osthole with baicalin protects mice from Staphylococcus aureus pneumonia.

Author information

1
Key Laboratory of Zoonosis, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.
2
Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.
3
Key Laboratory of Zoonosis, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China. jldxyzg@sohu.com.
4
Key Laboratory of Zoonosis, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China. wjf927@jlu.edu.cn.

Abstract

We reported the inhibition of α-Hemolysin (Hla) production in methicillin-resistant Staphylococcus aureus USA300 by osthole and further investigated the combination of osthole and baicalin in the treatment of staphylococcal pneumonia. Using cytotoxicity assays and a mouse model of intranasal lung infection, we evaluated the effect of combined therapy. Our results suggest that the combination of osthole and baicalin alleviated S. aureus-mediated A549 cell injury and protected mice from S. aureus pneumonia.

KEYWORDS:

Alpha-hemolysin; Baicalin; Osthole; Staphylococcus aureus

PMID:
27878749
DOI:
10.1007/s11274-016-2162-9
[Indexed for MEDLINE]

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