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Inflammation. 2017 Apr;40(2):697-707. doi: 10.1007/s10753-016-0480-6.

Role of Anti-inflammatory Cytokines IL-35 and IL-37 in Asthma.

Author information

1
Department of Respiratory Medicine, Affiliated Anhui Provincial Hospital, Anhui Medical University, 17 Lujiang Road, Hefei, Anhui, 230001, China. Hudaiju@163.com.

Abstract

Asthma is a chronic airway inflammation that is characterized by intense eosinophil infiltrates, mucus hypersecretion, airway remodeling, and airway hyperresponsiveness. Interleukin (IL)-35 and IL-37 are two cytokines with anti-inflammatory effects found in immune response. Recent findings suggested that expressions of IL-35 and IL-37 are abnormal in asthma. Functional analysis further confirmed the important roles of them in the pathogenesis of asthma. The present study reviewed the updated evidence indicating the roles of IL-35 and IL-37 in asthma. Hopefully, the information obtained may lead to a better understanding of the pathogenesis of the disease.

KEYWORDS:

IL-35; IL-37; asthma

PMID:
27878686
DOI:
10.1007/s10753-016-0480-6
[Indexed for MEDLINE]

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