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J Parasit Dis. 2016 Dec;40(4):1307-1310. Epub 2015 Mar 21.

In vitro and in vivo anthelmintic activity of seed extract of Coriandrum sativum compared to Niclosamid against Hymenolepis nana infection.

Author information

1
Biosatistics Department, University of Welfare and Rehabilitation, Tehran, Iran.
2
Biosatistics Department, University of Welfare and Rehabilitation, Tehran, Iran ; Division of Nursing, Shahid Modarres Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
3
Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical sciences, Isfahan, Iran.
4
Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran.
5
Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical sciences, Isfahan, Iran ; Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran.

Abstract

Phytotherapy can be an alternative for the control of gastrointestinal parasites in human and animals. Coriander (Coriandrum sativum L.) is a medicinal plant which grown as a spice crop all over the world. The seeds of this plant have been used to treat parasitic disease, indigestion, diabetes, rheumatism and pain in the joints. This study was carried out to compare the efficacy of Niclosamid and alcoholic seed extract of C. sativum on Hymenolepis nana infection, in vivo and vitro. For in vivo study, Balb/c mice were used, to compare the efficacy of 50 mg/kg body weight (B.W) of Niclosamid with different doses of alcoholic extracts of C. sativum (250, 500, and 750 mg/kg B.W). It was found that the efficacy of Niclosamid had reached 100 % after 11 days post treatment, while the efficacy of 500 and 750 mg/kg B.W of C. sativum reached to 100 % after 15 days after treatment. For in vitro study, special nutrient broth media was used. It was found that the addition of 1000 mg/ml of Niclosamid had paralyzed and killed worms within 5 min, while C. sativum killed them within 30 min. Our results showed that extract of C. sativum has good effect against H. nana and could be use in traditional medicine for treatment of parasitic disease.

KEYWORDS:

Anthelmintic activity; Coriandrum sativum; Hymenolepis nana; Niclosamid

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