Format

Send to

Choose Destination
Fitoterapia. 2017 Jan;116:72-76. doi: 10.1016/j.fitote.2016.11.008. Epub 2016 Nov 19.

Antimicrobial metabolites from the plant endophytic fungus Penicillium sp.

Author information

1
State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
2
State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China. Electronic address: cpu_lykong@126.com.

Abstract

Five rare dichloro aromatic polyketides (1-5) were obtained from an endophytic fungus Penicillium sp., along with five known metabolites (6-10). Their structures were elucidated by extensive spectroscopic analysis, Mosher methods, as well as [Rh2(OCOCF3)4]-induced electronic circular dichroism (ECD) experiments. Compounds 2-4 and 6 structurally involved acyclic 1.3-diols, the uneasy configuration determinations of which were well carried out by double-derivation NMR methods. Compounds 1-10 were evaluated for their antibacterial and antifungal activities against five strains of human pathogenic microorganisms. Helvolic acid (7) showed potent inhibitory effects against Staphylococcus aureus and Pseudomonas aeruginosa with MIC (minimum inhibitory concentration) values of 5.8 and 4.6μg/mL, respectively.

KEYWORDS:

(R)-MTPA-Cl (PubChem CID: 3080792); (S)-MTPA-Cl (PubChem CID: 2724611); 4-Dimethylaminopyridine (PubChem CID: 14284); Antimicrobial; Dichlorine; Ethyl ethanoate (PubChem CID: 8857); Penicillium sp.; Phenolic metabolites; Pyridine (PubChem CID: 1049)

PMID:
27876600
DOI:
10.1016/j.fitote.2016.11.008
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center