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Acta Obstet Gynecol Scand. 2017 Feb;96(2):139-143. doi: 10.1111/aogs.13065. Epub 2017 Jan 13.

The treatment of bacterial vaginosis in pregnancy with clindamycin to reduce the risk of infection-related preterm birth: a response to the Danish Society of Obstetrics and Gynecology guideline group's clinical recommendations.

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Division of Surgery, University College London, Northwick Park Institute for Medical Research Campus, London, UK.
Department of Gynecology and Obstetrics, Odense University Hospital, Research Unit of Gynecology and Obstetrics, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.
School of Women's and Infants' Health, The University of Western Australia, Perth, WA, Australia.
Department of Obstetrics and Gynecology, Skaraborg Hospital, University of Linköping, Skövde, Sweden.
Center for Innovative Medical Technology, Odense University Hospital, Odense, Denmark.


Preterm birth is the major cause of perinatal mortality and morbidity worldwide. Infection/inflammation is responsible for a significant percentage of preterm birth, particularly at early gestations. A recent clinical recommendation by a guidelines group of the Danish Society of Obstetrics and Gynecology advised against the use of clindamycin for the treatment of bacterial vaginosis in pregnancy to reduce the risk of spontaneous preterm birth based on lack of evidence of efficacy. We believe that the evidence for the use of clindamycin for this indication is robust and that this recommendation was reached erroneously on the basis of flawed inclusion criteria: the inclusion of an unpublished study with poorly diagnosed bacterial vaginosis and the exclusion of an important pivotal study on the use of clindamycin in early pregnancy for the prevention of preterm birth. Had these errors been corrected, the conclusions would have been different.


Antibiotics; bacterial vaginosis; clindamycin; infection; preterm birth; preterm labor; prevention

[Indexed for MEDLINE]

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