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Biol Open. 2016 Nov 15;5(11):1631-1641. doi: 10.1242/bio.018945.

MarvelD3 regulates the c-Jun N-terminal kinase pathway during eye development in Xenopus.

Author information

1
Institute of Ophthalmology, University College London, London EC1V 9EL, UK.
2
Division of Biomedical Sciences, Developmental Biomedical Science Laboratory, Graduate School of Biological Sciences, Nara Institute of Science and Technology (NAIST), 8916-5, Takayama-cho, Ikoma 630-0192, Japan.
3
Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.
4
Institute of Ophthalmology, University College London, London EC1V 9EL, UK k.matter@ucl.ac.uk.

Abstract

Ocular morphogenesis requires several signalling pathways controlling the expression of transcription factors and cell-cycle regulators. However, despite a well-known mechanism, the dialogue between those signals and factors remains to be unveiled. Here, we identify a requirement for MarvelD3, a tight junction transmembrane protein, in eye morphogenesis in Xenopus MarvelD3 depletion led to an abnormally pigmented eye or even an eye-less phenotype, which was rescued by ectopic MarvelD3 expression. Altering MarvelD3 expression led to deregulated expression of cell-cycle regulators and transcription factors required for eye development. The eye phenotype was rescued by increased c-Jun terminal Kinase activation. Thus, MarvelD3 links tight junctions and modulation of the JNK pathway to eye morphogenesis.

KEYWORDS:

C-Jun N-terminal Kinase; MarvelD3; Tight junction; Xenopus eye

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