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Radiology. 2016 Dec;281(3):969-974.

Case 236: Middle Interhemispheric Variant of Holoprosencephaly.

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From the Division of Neuroradiology (N.Y., O.R.I., I.I.), Section of Pediatric Neuroradiology, Division of Pediatric Radiology (A.P., T.A.H.), The Russell H. Morgan Department of Radiology and Radiologic Science, and Phelps Center for Cerebral Palsy and Neurodevelopmental Medicine, Kennedy Krieger Institute (A.H.H.), The Johns Hopkins University School of Medicine, 600 N Wolfe St, Phipps B-100, Baltimore, MD 21287.


History A 13-year-old girl presented for evaluation and further management of spastic diplegia cerebral palsy. Absence of the corpus callosum was noted at screening prenatal head ultrasonography. She was born at full term via spontaneous vaginal delivery. Physical examination revealed decreased axial muscle tone and increased muscle tone in her extremities; the latter was more severe. She was nonambulatory. No midline craniofacial anomaly was seen. She had dysarthria but was able to speak in full sentences. She was in sixth grade with an individualized education program. She had mild behavioral problems, such as "acting out" in school. Brain magnetic resonance (MR) imaging, including three-dimensional T1- and T2-weighted sequences, was performed without intravenous administration of contrast material to evaluate the brain.


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