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Int J Cancer. 2017 Mar 1;140(5):1111-1118. doi: 10.1002/ijc.30528. Epub 2016 Dec 27.

Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition.

Author information

1
Nuffield Department of Population Health, Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom.
2
Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, United Kingdom.
3
Center for Chronic Immunodeficiency, Molecular Epidemiology, University Medical Center Freiburg, Freiburg, Germany.
4
Institute for Risk Assessment Sciences, Division Environmental Epidemiology, Utrecht University, Utrecht, The Netherlands.
5
Centre d'Immunologie de Marseille-Luminy, Université d'Aix-Marseille UM2, Inserm, U1104, CNRS, Marseille, France.
6
Unit of Infections and Cancer (UNIC), IDIBELL, Institut Català d'Oncologia, 08907 L'Hospitalet de Llobregat, Barcelona, Spain.
7
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
8
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
9
Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.
10
Hellenic Health Foundation, Athens, Greece.
11
Department of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, University of Athens Medical School, Greece.
12
Department of Clinical Sciences and Community Health Università degli Studi di Milano, Italy.
13
Danish Cancer Society Research Center, Copenhagen, Denmark.
14
Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France.
15
Gustave Roussy, Villejuif, France.
16
CHU Rennes, University Rennes 1, Rennes, France.
17
Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
18
Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute-ISPO, Florence, Italy.
19
Unit of Cancer Epidemiology, AO Citta' della Salute e della Scienza-University of Turin and Center for Cancer Prevention (CPO-Piemonte), Turin, Italy.
20
Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands.
21
Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College, London, United Kingdom.
22
Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
23
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
24
Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
25
Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.
26
Department of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway.
27
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
28
Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland.
29
Basque Regional Health Department San Sebastian, Public Health Direction and Biodonostia- Ciberesp, Spain.
30
Public Health Directorate, Asturias, Spain.
31
Navarra Public Health Institute, Pamplona, Spain.
32
Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
33
Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain.
34
Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
35
Department of Clinical Sciences Lund, Division of Oncology and Pathology, Lund University, Faculty of Medicine, Lund, Sweden.
36
Department of Radiation Sciences, Oncology Umeå University, Umeå, Sweden.
37
MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
38
University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.
39
Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.

Abstract

Insulin-like growth factor (IGF)-I has cancer promoting activities. However, the hypothesis that circulating IGF-I concentration is related to risk of lymphoma overall or its subtypes has not been examined prospectively. IGF-I concentration was measured in pre-diagnostic plasma samples from a nested case-control study of 1,072 cases of lymphoid malignancies and 1,072 individually matched controls from the European Prospective Investigation into Cancer and Nutrition. Odds ratios (ORs) and confidence intervals (CIs) for lymphoma were calculated using conditional logistic regression. IGF-I concentration was not associated with overall lymphoma risk (multivariable-adjusted OR for highest versus lowest third = 0.77 [95% CI = 0.57-1.03], ptrend  = 0.06). There was no statistical evidence of heterogeneity in this association with IGF-I by sex, age at blood collection, time between blood collection and diagnosis, age at diagnosis, or body mass index (pheterogeneity for all  ≥ 0.05). There were no associations between IGF-I concentration and risk for specific BCL subtypes, T-cell lymphoma or Hodgkin lymphoma, although number of cases were small. In this European population, IGF-I concentration was not associated with risk of overall lymphoma. This study provides the first prospective evidence on circulating IGF-I concentrations and risk of lymphoma. Further prospective data are required to examine associations of IGF-I concentrations with lymphoma subtypes.

KEYWORDS:

EPIC cohort; IGF-I; lymphoma; nested case-control; non-Hodgkin lymphoma; plasma; prospective

PMID:
27870006
PMCID:
PMC5299544
DOI:
10.1002/ijc.30528
[Indexed for MEDLINE]
Free PMC Article

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