Format

Send to

Choose Destination
Nat Genet. 2017 Jan;49(1):27-35. doi: 10.1038/ng.3725. Epub 2016 Nov 21.

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects.

Marshall CR1, Howrigan DP2,3, Merico D1, Thiruvahindrapuram B1, Wu W4,5, Greer DS4,5, Antaki D4,5, Shetty A4,5, Holmans PA6,7, Pinto D8,9, Gujral M4,5, Brandler WM4,5, Malhotra D4,5,10, Wang Z1, Fajarado KVF4,5, Maile MS4,5, Ripke S2,3, Agartz I11,12,13, Albus M14, Alexander M15, Amin F16,17, Atkins J18,19, Bacanu SA20, Belliveau RA Jr3, Bergen SE3,21, Bertalan M22,23, Bevilacqua E3, Bigdeli TB20, Black DW24, Bruggeman R25, Buccola NG26, Buckner RL27,28,29, Bulik-Sullivan B2,3, Byerley W30, Cahn W31, Cai G8,32, Cairns MJ18,33,34, Campion D35, Cantor RM36, Carr VJ33,37, Carrera N6, Catts SV33,38, Chambert KD3, Cheng W39, Cloninger CR40, Cohen D41, Cormican P42, Craddock N6,7, Crespo-Facorro B43,44, Crowley JJ45, Curtis D46,47, Davidson M48, Davis KL8, Degenhardt F49,50, Del Favero J51, DeLisi LE52,53, Dikeos D54, Dinan T55, Djurovic S11,56, Donohoe G42,57, Drapeau E8, Duan J58,59, Dudbridge F60, Eichhammer P61, Eriksson J62,63,64, Escott-Price V6, Essioux L65, Fanous AH66,67,68,69, Farh KH2, Farrell MS45, Frank J70, Franke L71, Freedman R72, Freimer NB73, Friedman JI8, Forstner AJ49,50, Fromer M2,3,74,75, Genovese G3, Georgieva L6, Gershon ES59,76, Giegling I77,78, Giusti-Rodríguez P45, Godard S79, Goldstein JI2,80, Gratten J81, de Haan L82, Hamshere ML6, Hansen M83, Hansen T22,23, Haroutunian V8,84,85, Hartmann AM77, Henskens FA33,34,86, Herms S49,50,87, Hirschhorn JN80,88,89, Hoffmann P49,50,87, Hofman A49,50, Huang H2,80, Ikeda M90, Joa I91, Kähler AK21, Kahn RS31, Kalaydjieva L92,93, Karjalainen J71, Kavanagh D6, Keller MC94, Kelly BJ34, Kennedy JL95,96,97, Kim Y45, Knowles JA69,98, Konte B77, Laurent C15,99, Lee P2,3,75, Lee SH81, Legge SE6, Lerer B100, Levy DL53,101, Liang KY102, Lieberman J103, Lönnqvist J104, Loughland CM33,34, Magnusson PKE21, Maher BS105, Maier W106, Mallet J107, Mattheisen M23,108,109,110, Mattingsdal M11,111, McCarley RW52,53, McDonald C112, McIntosh AM113,114, Meier S70, Meijer CJ82, Melle I11,115, Mesholam-Gately RI53,116, Metspalu A117, Michie PT33,118, Milani L117, Milanova V119, Mokrab Y120, Morris DW42,57, Müller-Myhsok B121,122,123, Murphy KC124, Murray RM125, Myin-Germeys I126, Nenadic I127, Nertney DA128, Nestadt G129, Nicodemus KK130, Nisenbaum L131, Nordin A132, O'Callaghan E133, O'Dushlaine C3, Oh SY134, Olincy A72, Olsen L22,23, O'Neill FA135, Van Os J126,125, Pantelis C33,136, Papadimitriou GN54, Parkhomenko E8, Pato MT69,98, Paunio T137; Psychosis Endophenotypes International Consortium, Perkins DO138, Pers TH80,89,139, Pietiläinen O137,140, Pimm J47, Pocklington AJ6, Powell J125, Price A80,141, Pulver AE129, Purcell SM74, Quested D142, Rasmussen HB22,23, Reichenberg A8,85, Reimers MA20, Richards AL6,7, Roffman JL28,29, Roussos P74,143, Ruderfer DM6,74, Salomaa V63, Sanders AR58,59, Savitz A144, Schall U33,34, Schulze TG70,145, Schwab SG146, Scolnick EM3, Scott RJ18,33,147, Seidman LJ53,116, Shi J148, Silverman JM8,149, Smoller JW3,75, Söderman E13, Spencer CCA150, Stahl EA74,80, Strengman E31,151, Strohmaier J70, Stroup TS103, Suvisaari J104, Svrakic DM40, Szatkiewicz JP45, Thirumalai S152, Tooney PA18,33,34, Veijola J153,154, Visscher PM81, Waddington J155, Walsh D156, Webb BT20, Weiser M48, Wildenauer DB157, Williams NM6, Williams S45, Witt SH70, Wolen AR20, Wormley BK20, Wray NR81, Wu JQ18,33, Zai CC95,96, Adolfsson R132, Andreassen OA11,115, Blackwood DHR113, Bramon E158, Buxbaum JD8,32,85,159, Cichon S49,50,87,160, Collier DA120,161, Corvin A42, Daly MJ2,3,80, Darvasi A162, Domenici E10,163, Esko T80,88,89,117, Gejman PV58,59, Gill M42, Gurling H47, Hultman CM21, Iwata N90, Jablensky AV33,93,157,164, Jönsson EG11,13, Kendler KS20, Kirov G6, Knight J95,96,97, Levinson DF15, Li QS144, McCarroll SA3,88, McQuillin A47, Moran JL3, Mowry BJ81,128, Nöthen MM49,50, Ophoff RA31,36,73, Owen MJ6,7, Palotie A3,75,140, Pato CN69,98, Petryshen TL3,29,53,165, Posthuma D166,167,168, Rietschel M70, Riley BP20, Rujescu D77,78, Sklar P74,85,143, St Clair D169, Walters JTR6, Werge T22,23,170, Sullivan PF21,45,138, O'Donovan MC6,7, Scherer SW1,171, Neale BM2,3,75,80, Sebat J4,5,172; CNV and Schizophrenia Working Groups of the Psychiatric Genomics Consortium.

Author information

1
Centre for Applied Genomics and Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
2
Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
3
Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
4
Beyster Center for Psychiatric Genomics, University of California, San Diego, La Jolla, California, USA.
5
Department of Psychiatry, University of California, San Diego, La Jolla, California, USA.
6
MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK.
7
National Centre for Mental Health, Cardiff University, Cardiff, UK.
8
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
9
Department of Genetics and Genomic Sciences, Seaver Autism Center, Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
10
Neuroscience Discovery and Translational Area, Pharma Research and Early Development, F. Hoffmann-La Roche, Ltd, Basel, Switzerland.
11
NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
12
Department of Psychiatry, Diakonhjemmet Hospital, Oslo, Norway.
13
Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm, Sweden.
14
State Mental Hospital, Haar, Germany.
15
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA.
16
Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia, USA.
17
Department of Psychiatry and Behavioral Sciences, Atlanta Veterans Affairs Medical Center, Atlanta, Georgia, USA.
18
School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia.
19
Hunter Medical Research Institute, New Lambton, New South Wales, Australia.
20
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA.
21
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
22
Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Mental Health Services Copenhagen, Copenhagen, Denmark.
23
Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark.
24
Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
25
Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
26
School of Nursing, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
27
Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA.
28
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.
29
Athinoula A. Martinos Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
30
Department of Psychiatry, University of California at San Francisco, San Francisco, California, USA.
31
Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, the Netherlands.
32
Department of Human Genetics, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
33
Schizophrenia Research Institute, Sydney, New South Wales, Australia.
34
Priority Centre for Translational Neuroscience and Mental Health, University of Newcastle, Newcastle, New South Wales, Australia.
35
Centre Hospitalier du Rouvray and INSERM U1079, Faculty of Medicine, Rouen, France.
36
Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
37
School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
38
Department of Psychiatry, Royal Brisbane and Women's Hospital, University of Queensland, Brisbane, Queensland, Australia.
39
Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
40
Department of Psychiatry, Washington University, St. Louis, Missouri, USA.
41
Department of Child and Adolescent Psychiatry, Assistance Publique-Hospitaux de Paris, Pierre and Marie Curie Faculty of Medicine and Institute for Intelligent Systems and Robotics, Paris, France.
42
Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Dublin, Ireland.
43
Instituto de Formación e Investigación Marqués de Valdecilla, University Hospital Marqués de Valdecilla, University of Cantabria, Santander, Spain.
44
Centro Investigación Biomédica en Red Salud Mental, Madrid, Spain.
45
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
46
Department of Psychological Medicine, Queen Mary University of London, London, UK.
47
Molecular Psychiatry Laboratory, Division of Psychiatry, University College London, London, UK.
48
Department of Psychiatry, Sheba Medical Center, Tel Hashomer, Israel.
49
Institute of Human Genetics, University of Bonn, Bonn, Germany.
50
Department of Genomics, Life and Brain Center, Bonn, Germany.
51
Applied Molecular Genomics Unit, VIB Department of Molecular Genetics, University of Antwerp, Antwerp, Belgium.
52
Virginia Boston Health Care System, Brockton, Massachusetts, USA.
53
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
54
First Department of Psychiatry, University of Athens Medical School, Athens, Greece.
55
Department of Psychiatry, University College Cork, Cork, Ireland.
56
Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
57
Cognitive Genetics and Therapy Group, School of Psychology and Discipline of Biochemistry, National University of Ireland Galway, Galway, Ireland.
58
Department of Psychiatry and Behavioral Sciences, NorthShore University HealthSystem, Evanston, Illinois, USA.
59
Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA.
60
Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
61
Department of Psychiatry, University of Regensburg, Regensburg, Germany.
62
Folkhälsan Research Center and Biomedicum Helsinki, Helsinki, Finland.
63
National Institute for Health and Welfare, Helsinki, Finland.
64
Department of General Practice, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.
65
Translational Technologies and Bioinformatics, Pharma Research and Early Development, F. Hoffman-La Roche, Basel, Switzerland.
66
Mental Health Service Line, Washington Virginia Medical Center, Washington, DC, USA.
67
Department of Psychiatry, Georgetown University, Washington, DC, USA.
68
Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA.
69
Department of Psychiatry, Keck School of Medicine at the University of Southern California, Los Angeles, California, USA.
70
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
71
Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
72
Department of Psychiatry, University of Colorado Denver, Aurora, Colorado, USA.
73
Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California, USA.
74
Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
75
Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
76
Department of Human Genetics, University of Chicago, Chicago, Illinois, USA.
77
Department of Psychiatry, University of Halle, Halle, Germany.
78
Department of Psychiatry, University of Munich, Munich, Germany.
79
Departments of Psychiatry, and Human and Molecular Genetics, INSERM, Institut de Myologie, Hôpital de la Pitiè-Salpêtrière, Paris, France.
80
Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
81
Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
82
Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands.
83
Illumina, Inc., La Jolla, California, USA.
84
J.J. Peters Virginia Medical Center, Bronx, New York, USA.
85
Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
86
School of Electrical Engineering and Computer Science, University of Newcastle, Newcastle, New South Wales, Australia.
87
Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.
88
Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
89
Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, USA.
90
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan.
91
Regional Centre for Clinical Research in Psychosis, Department of Psychiatry, Stavanger University Hospital, Stavanger, Norway.
92
Centre for Medical Research, University of Western Australia, Perth, Western Australia, Australia.
93
Perkins Institute for Medical Research, University of Western Australia, Perth, Western Australia, Australia.
94
Department of Psychology, University of Colorado Boulder, Boulder, Colorado, USA.
95
Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
96
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
97
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
98
Zilkha Neurogenetics Institute, Keck School of Medicine at the University of Southern California, Los Angeles, California, USA.
99
Department of Child and Adolescent Psychiatry, Pierre and Marie Curie Faculty of Medicine, Paris, France.
100
Department of Psychiatry, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
101
Psychology Research Laboratory, McLean Hospital, Belmont, Massachusetts, USA.
102
Department of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
103
Department of Psychiatry, Columbia University, New York, New York, USA.
104
Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland.
105
Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
106
Department of Psychiatry, University of Bonn, Bonn, Germany.
107
CNRS, Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs, Hôpital de la Pitié-Salpêtrière, Paris, France.
108
Department of Biomedicine, Aarhus University, Aarhus, Denmark.
109
Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark.
110
Department of Genomics Mathematics, University of Bonn, Bonn, Germany.
111
Research Unit, Sørlandet Hospital, Kristiansand, Norway.
112
Department of Psychiatry, National University of Ireland Galway, Galway, Ireland.
113
Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
114
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
115
Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
116
Massachusetts Mental Health Center Public Psychiatry Division of the Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
117
Estonian Genome Center, University of Tartu, Tartu, Estonia.
118
School of Psychology, University of Newcastle, Newcastle, New South Wales, Australia.
119
First Psychiatric Clinic, Medical University, Sofia, Bulgaria.
120
Eli Lilly and Company, Ltd., Windlesham, UK.
121
Max Planck Institute of Psychiatry, Munich, Germany.
122
Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
123
Cluster for Systems Neurology (SyNergy), Munich, Germany.
124
Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland.
125
Institute of Psychiatry, King's College London, London, UK.
126
Maastricht University Medical Centre, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht, the Netherlands.
127
Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
128
Queensland Centre for Mental Health Research, University of Queensland, Brisbane, Queensland, Australia.
129
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
130
Department of Psychiatry, Trinity College Dublin, Dublin, Ireland.
131
Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, USA.
132
Department of Clinical Sciences, Psychiatry, Umeå University, Umeå, Sweden.
133
DETECT Early Intervention Service for Psychosis, Blackrock, Ireland.
134
Lawrence Berkeley National Laboratory, University of California at Berkeley, Berkeley, California, USA.
135
Centre for Public Health, Institute of Clinical Sciences, Queen's University Belfast, Belfast, UK.
136
Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Melbourne, Victoria, Australia.
137
Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland.
138
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
139
Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Denmark.
140
Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.
141
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.
142
Department of Psychiatry, University of Oxford, Oxford, UK.
143
Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
144
Neuroscience Therapeutic Area, Janssen Research and Development, Raritan, New Jersey, USA.
145
Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Germany.
146
Psychiatry and Psychotherapy Clinic, University of Erlangen, Erlangen, Germany.
147
Hunter New England Health Service, Newcastle, New South Wales, Australia.
148
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
149
Research and Development, Bronx Veterans Affairs Medical Center, New York, New York, USA.
150
Wellcome Trust Centre for Human Genetics, Oxford, UK.
151
Department of Medical Genetics, University Medical Centre Utrecht, Utrecht, the Netherlands.
152
Berkshire Healthcare NHS Foundation Trust, Bracknell, UK.
153
Department of Psychiatry, University of Oulu, Oulu, Finland.
154
Department of Psychiatry, University Hospital of Oulu, Oulu, Finland.
155
Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
156
Health Research Board, Dublin, Ireland.
157
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Western Australia, Australia.
158
Division of Psychiatry, University College London, London, UK.
159
Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
160
Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany.
161
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
162
Department of Genetics, Hebrew University of Jerusalem, Jerusalem, Israel.
163
Centre for Integrative Biology, University of Trento, Trento, Italy.
164
Centre for Clinical Research in Neuropsychiatry, School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Western Australia, Australia.
165
Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.
166
Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, Amsterdam, the Netherlands.
167
Department of Complex Trait Genetics, Neuroscience Campus Amsterdam, VU University Medical Center Amsterdam, Amsterdam, the Netherlands.
168
Department of Child and Adolescent Psychiatry, Erasmus University Medical Centre, Rotterdam, the Netherlands.
169
Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
170
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
171
Department of Molecular Genetics and McLaughlin Centre, University of Toronto, Toronto, Ontario, Canada.
172
Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California, USA.

Abstract

Copy number variants (CNVs) have been strongly implicated in the genetic etiology of schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has been hampered by limited sample sizes. We sought to address this obstacle by applying a centralized analysis pipeline to a SCZ cohort of 21,094 cases and 20,227 controls. A global enrichment of CNV burden was observed in cases (odds ratio (OR) = 1.11, P = 5.7 × 10-15), which persisted after excluding loci implicated in previous studies (OR = 1.07, P = 1.7 × 10-6). CNV burden was enriched for genes associated with synaptic function (OR = 1.68, P = 2.8 × 10-11) and neurobehavioral phenotypes in mouse (OR = 1.18, P = 7.3 × 10-5). Genome-wide significant evidence was obtained for eight loci, including 1q21.1, 2p16.3 (NRXN1), 3q29, 7q11.2, 15q13.3, distal 16p11.2, proximal 16p11.2 and 22q11.2. Suggestive support was found for eight additional candidate susceptibility and protective loci, which consisted predominantly of CNVs mediated by nonallelic homologous recombination.

PMID:
27869829
PMCID:
PMC5737772
DOI:
10.1038/ng.3725
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center