Fluorogenic 2D Peptidosheet Unravels CD47 as a Potential Biomarker for Profiling Hepatocellular Carcinoma and Cholangiocarcinoma Tissues

Yun-Han Ma; Wei-Tao Dou; Yu-Fei Pan; Li-Wei Dong; Ye-Xiong Tan; Xiao-Peng He; He Tian; Hong-Yang Wang

doi:10.1002/adma.201604253

Fluorogenic 2D Peptidosheet Unravels CD47 as a Potential Biomarker for Profiling Hepatocellular Carcinoma and Cholangiocarcinoma Tissues

Adv Mater. 2017 Feb;29(5). doi: 10.1002/adma.201604253. Epub 2016 Nov 21.

Authors

Yun-Han Ma¹, Wei-Tao Dou², Yu-Fei Pan¹, Li-Wei Dong¹, Ye-Xiong Tan¹, Xiao-Peng He², He Tian², Hong-Yang Wang¹

Affiliations

¹ International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, the Second Military Medical University, Shanghai, 200433, P. R. China.
² Key Laboratory for Advanced Materials & Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd., Shanghai, 200237, P. R. China.

PMID: 27869342
DOI: 10.1002/adma.201604253

Abstract

A 2D peptidosheet unravels CD47 as a potential biomarker to image hepatocarcinoma and cholangiocarcinoma cells and tissues. Supramolecular assembly between water-soluble 2D MoS₂ and a peptide probe produces the 2D peptidosheet suited for the profiling of hepatocarcinoma and cholangiocarcinoma tissues over healthy tissues on clinical specimens.

Keywords: 2D materials; CD47; biomarkers; cancer; imaging.

MeSH terms

Bile Duct Neoplasms
Bile Ducts, Intrahepatic
Biomarkers, Tumor
CD47 Antigen / chemistry*
Carcinoma, Hepatocellular
Cholangiocarcinoma
Humans
Liver Neoplasms
Peptides

Substances

Biomarkers, Tumor
CD47 Antigen
Peptides