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Mol Neuropsychiatry. 2016 Oct;2(3):124-132. Epub 2016 Jul 21.

Dopamine D2L Receptor Is Required for Visual Discrimination and Reversal Learning.

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Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Department of Pharmacology and Beckman Institute, University of Illinois, Urbana-Champaign, Ill., USA.
Brain Research Institute, Niigata University, Niigata, Japan.
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Md., USA.


The corticostriatothalamic circuit regulates learning behaviors via dopamine neurotransmission. D2 long (D2L) receptors are an isoform of dopamine D2 receptors (D2Rs) and may act mainly at postsynaptic sites. It is well known that D2Rs influence high brain functions, but the roles of individual D2R isoforms are still unclear. To assess the influence of D2L receptors in visual discrimination learning, we performed visual discrimination and reversal tasks with D2L knockout mice using a touchscreen operant system. There were no significant differences in an operant conditioning task between genotypes. However, D2L knockout mice were impaired in both visual discrimination and reversal learning tasks. D2L knockout mice were also significantly slower than wild-type mice in collecting the reward in the visual discrimination task. These results indicate that D2L receptors play an important role in visual discrimination and reversal learning.


Dopamine receptor; Flexibility; Touchscreen

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