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Clin Immunol Immunopathol. 1989 Aug;52(2):238-47.

Constitutive production of interleukin 6/B cell stimulatory factor-2 from inflammatory synovium.

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Division of Clinical Immunology, Tokyo Women's Medical College, Japan.


Interleukin 6 (IL-6) production from synovial tissues of various diseases was examined. Augmented IL-6 production was found in inflammatory synovium not only in RA but also in other kinds of synovitis, including psoriatic arthritis and Beh├žet's disease. Increased amounts of IL-6-mRNA were detected in rheumatoid synovium using a dot blot hydridization technique. Furthermore, there was a positive correlation between IL-6 production and accumulation of plasma cells in the synovium. These findings suggest that IL-6 plays an important role not only in immune response but also in active inflammation in various kinds of synovitis.

[Indexed for MEDLINE]

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