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Cell Mol Immunol. 2018 Mar;15(3):246-259. doi: 10.1038/cmi.2016.49. Epub 2016 Nov 21.

p38α has an important role in antigen cross-presentation by dendritic cells.

Author information

1
Institute for Immunology, School of Medicine, Tsinghua University, Beijing 100084, China.
2
State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen 361005, Fujian, China.
3
State Key Laboratory of Biomembrane, National Engineering Laboratory for Anti-tumor Therapeutics, School of Medicine, Tsinghua University, Beijing 100084, China.
4
Tsinghua-Peking Joint Center for Life Sciences, Beijing 100084, China.

Abstract

The role of the p38 signaling pathway in the innate and adaptive immune responses has been well documented, especially in inflammatory cytokine production by dendritic cells (DCs). However, whether the p38 signaling pathway affects the important antigen (Ag) presentation function of DCs remains largely unknown. In this study, we reported that the deletion of p38α resulted in an impaired cross-presentation ability of CD8+ conventional DCs (cDCs) and a reduction in the direct presentation ability of CD8- cDCs ex vivo. Further study revealed that p38α had a crucial role in Ag processing by CD8+ cDCs but did not affect the Ag uptake or co-stimulation of T cells. Moreover, p38α deficiency led to reduced cross-priming of T cells in vivo. The production of the IL-12p40 and IL-12p70 cytokines by p38α-deficient cDCs was also significantly reduced. Our study identified a new role for p38α in modulating the important antigen cross-presentation function of DCs.

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