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Clin Rheumatol. 2017 Jan;36(1):83-88. doi: 10.1007/s10067-016-3472-x. Epub 2016 Nov 18.

Characteristics of primary Sjögren's syndrome patients with IgG4 positive plasma cells infiltration in the labial salivary glands.

Author information

1
Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing Medical University, Nanjing, 210008, China.
2
Department of Rheumatology and Immunology, Dalian Municipal Central Hospital, Dalian, China.
3
Department of Pathology and Center of Infection and Immunology, The University of Hong Kong, Hong Kong, China.
4
Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, Jiangsu, 210029, China. lgu@njmu.edu.cn.
5
Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing Medical University, Nanjing, 210008, China. lingyunsun@nju.edu.cn.

Abstract

The purpose of this study was to investigate the characteristics of primary Sjögren's syndrome (pSS) patients with IgG4 positive (IgG4+) plasma cell infiltration in labial salivary glands (LSGs). Paraffin sections of LSGs from 336 pSS patients were stained with IgG4 and IgG monoclonal antibodies. According to the infiltration of IgG4+ plasma cells, patients were divided and clinical and serological characteristics were analyzed and compared. Based on the infiltration of IgG4+ plasma cells in the LSGs, patients were divided into three subgroups, low IgG4, moderate IgG4, and high IgG4 groups. A negative association between the number of infiltrated IgG4+ plasma cells and the disease characteristics was observed. We found that the higher the IgG4+ expression in plasma cells, the lower the positive rates of serum anti-SSA antibodies, anti-SSB antibodies, antinuclear antibodies (ANA), and rheumatoid factor (RF). Besides, patients from the high IgG4 group had the highest frequency of interstitial lung disease (ILD, 30.6%) and tubulointerstitial nephritis (TIN, 13.9%), but the lowest frequency of leucopenia (13.9%), thrombocytopenia (11.1%), and abnormal thyroidal function (0%). PSS patients with different IgG4+ plasma cells infiltration in the LSGs had distinctive clinical and laboratory characteristics. It may help us to further understand the role of IgG4+ plasma cells in pSS.

KEYWORDS:

IgG4-positive plasma cells; IgG4-related diseases; Primary Sjögren’s syndrome

PMID:
27864697
DOI:
10.1007/s10067-016-3472-x
[Indexed for MEDLINE]

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