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J Immunol. 2016 Dec 1;197(11):4210-4218.

Immune-Mediated Protection and Pathogenesis of Chikungunya Virus.

Fox JM1, Diamond MS2,3,4,5.

Author information

1
Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
2
Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110; diamond@wusm.wustl.edu.
3
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.
4
Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110; and.
5
Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110.

Abstract

Chikungunya virus (CHIKV) is a re-emerging alphavirus that causes debilitating acute and chronic arthritis. Infection by CHIKV induces a robust immune response that is characterized by production of type I IFNs, recruitment of innate and adaptive immune cells, and development of neutralizing Abs. Despite this response, chronic arthritis can develop in some individuals, which may be due to a failure to eliminate viral RNA and Ag and/or persistent immune responses that cause chronic joint inflammation. In this review, based primarily on advances from recent studies in mice, we discuss the innate and adaptive immune factors that control CHIKV dissemination and clearance or contribute to pathogenesis.

PMID:
27864552
PMCID:
PMC5120763
DOI:
10.4049/jimmunol.1601426
[Indexed for MEDLINE]
Free PMC Article

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