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Int J Pharm. 2016 Nov 30;514(1):41-51. doi: 10.1016/j.ijpharm.2016.06.004.

Combinatorial nanodiamond in pharmaceutical and biomedical applications.

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College of Pharmacy, Dongguk University-Seoul, Gyeonggi, Republic of Korea.
School of Chemical Engineering and Material Science, Chung-Ang University, 221 Heukseok-Dong, Dongjak-Gu, Seoul, Republic of Korea. Electronic address:
Departments of Pharmaceutics and Biomedical Engineering, Purdue University, West Lafayette, IN 47907, United States.
College of Pharmacy, Dongguk University-Seoul, Gyeonggi, Republic of Korea. Electronic address:


One of the newly emerging carbon materials, nanodiamond (ND), has been exploited for use in traditional electric materials and this has extended into biomedical and pharmaceutical applications. Recently, NDs have attained significant interests as a multifunctional and combinational drug delivery system. ND studies have provided insights into granting new potentials with their wide ranging surface chemistry, complex formation with biopolymers, and combination with biomolecules. The studies that have proved ND inertness, biocompatibility, and low toxicity have made NDs much more feasible for use in real in vivo applications. This review gives an understanding of NDs in biomedical engineering and pharmaceuticals, focusing on the classified introduction of ND/drug complexes. In addition, the diverse potential applications that can be obtained with chemical modification are presented.


Complex formation; Drug delivery; Nanodiamond; Surface

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