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Pediatr Obes. 2017 Aug;12 Suppl 1:125-129. doi: 10.1111/ijpo.12192. Epub 2016 Nov 10.

The relationship between breast milk leptin and adiponectin with child body composition from 3 to 5 years: a follow-up study.

Author information

1
From the Else Kröner-Fresenius-Center for Nutritional Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
2
Institute of Diabetes Research, Helmholtz Zentrum München, Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
3
ZIEL - Institute for Food and Health, Nutritional Medicine Unit, Technische Universität München, Freising, Germany.

Abstract

BACKGROUND:

Research indicates that breast milk contains bioactive components that influence metabolism in infancy and may play a role in the prevention of obesity in early childhood. In our initial study, 147 breastfeeding mother/child pairs were followed from birth to 2 years of age to examine the relationship between breast milk leptin and total adiponectin (collected at 6 weeks and 4 months postpartum) and infant body composition. Higher breast milk total adiponectin was related to greater fat mass and weight gain in children at 1 and 2 years of age, whereas leptin showed no association.

OBJECTIVES/METHODS:

In this follow-up, we examined the relationship between both adipokines and children's body weight, body mass index percentiles, sum of four skin-folds, percentage of body fat, fat mass and lean body mass at 3, 4 and 5 years of age.

RESULTS:

Breast milk adipokines were largely unrelated to child anthropometric measures.

CONCLUSION:

Our results do not provide significant evidence that breast milk adipokines can predict adiposity in preschool children.

KEYWORDS:

Adipokines; adiponectin; breast milk; childhood obesity

PMID:
27863153
DOI:
10.1111/ijpo.12192
[Indexed for MEDLINE]
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