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Obes Rev. 2017 Jan;18(1):18-31. doi: 10.1111/obr.12484. Epub 2016 Nov 11.

Gut microbial metabolism defines host metabolism: an emerging perspective in obesity and allergic inflammation.

Author information

1
Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
2
Department of Obstetrics and Gynecology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
3
School of Public Health, University of Alberta, Edmonton, AB, Canada.

Abstract

The presence of >100 trillion microorganisms (collectively called gut microbiota) in our large intestine is essential for the maintenance of health. The gut microbiota starts to develop before birth and matures within first three years of life. The Western diet and lifestyle have been implicated in causing an imbalance of gut microbial communities and their metabolites that consequence in disease states, such as obesity and asthma. With more than 13% of the world population currently living with obesity and one out of 10 children diagnosed with asthma, we explore here the recent developments in the biosynthesis and mode of action of the key metabolites in relation to these two chronic inflammatory conditions.

KEYWORDS:

Gut; microbiota; overweight; short chain fatty acids

PMID:
27862824
DOI:
10.1111/obr.12484
[Indexed for MEDLINE]

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