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Dermatol Ther. 2017 Mar;30(2). doi: 10.1111/dth.12445. Epub 2016 Nov 12.

Two diseases one remedy? Systemic amyloidosis secondary to hidradenitis suppurativa: Treatment with infliximab.

Author information

1
Meram Faculty of Medicine, Department of Dermatology, Necmettin Erbakan University, Konya, Turkey.
2
Department of Nephrology, Gazi University Faculty of Medicine, Ankara, Turkey.
3
Department of Dermatology, Gazi University Faculty of Medicine, Ankara, Turkey.

Abstract

Hidradenitis suppurativa, known as acne inversa, is a relapsing and chronic inflammatory skin disease affecting the skin folds. During the chronic course of the disease many local complications like fistulae to other tissues or systemic complications including anemia, secondary amyloidosis, lymphedema, nephrotic syndrome, artropathy may take place. Amyloid A amyloidosis is a rare complication of hidradenitis suppurativa, which has been described in a limited number of case reports. Herein, we present such a patient that had developed AA amyloidosis during the course of hidradenitis suppurativa. Both AA amyloidosis and hidradenitis suppurativa have responded to infliximab therapy which was shown by clinical recovery and by the improvement in renal functions.

KEYWORDS:

hidradenitis suppurativa; infliximab; systemic amyloidosis

PMID:
27862787
DOI:
10.1111/dth.12445
[Indexed for MEDLINE]

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