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Chemistry. 2016 Dec 19;22(51):18419-18428. doi: 10.1002/chem.201603091. Epub 2016 Nov 10.

Study of (Cyclic Peptide)-Polymer Conjugate Assemblies by Small-Angle Neutron Scattering.

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School of Chemistry, The University of Sydney, NSW 2006, Australia.
Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, VIC 3052, Australia.


We present a fundamental study into the self-assembly of (cyclic peptide)-polymer conjugates as a versatile supramolecular motif to engineer nanotubes with defined structure and dimensions, as characterised in solution using small-angle neutron scattering (SANS). This work demonstrates the ability of the grafted polymer to stabilise and/or promote the formation of unaggregated nanotubes by the direct comparison to the unconjugated cyclic peptide precursor. This ideal case permitted a further study into the growth mechanism of self-assembling cyclic peptides, allowing an estimation of the cooperativity. Furthermore, we show the dependency of the nanostructure on the polymer and peptide chemical functionality in solvent mixtures that vary in the ability to compete with the intermolecular associations between cyclic peptides and ability to solvate the polymer shell.


cyclic peptide; nanotubes; polymer conjugates; raft polymerization; self-assembly; supramolecular


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