Format

Send to

Choose Destination
PLoS Biol. 2016 Nov 18;14(11):e2000225. doi: 10.1371/journal.pbio.2000225. eCollection 2016 Nov.

Phylosymbiosis: Relationships and Functional Effects of Microbial Communities across Host Evolutionary History.

Author information

1
Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, United States of America.
2
Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee, United States of America.
3
The Rowland Institute at Harvard, Harvard University, Cambridge, Massachusetts, United States of America.
4
Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee, United States of America.

Abstract

Phylosymbiosis was recently proposed to describe the eco-evolutionary pattern, whereby the ecological relatedness of host-associated microbial communities parallels the phylogeny of related host species. Here, we test the prevalence of phylosymbiosis and its functional significance under highly controlled conditions by characterizing the microbiota of 24 animal species from four different groups (Peromyscus deer mice, Drosophila flies, mosquitoes, and Nasonia wasps), and we reevaluate the phylosymbiotic relationships of seven species of wild hominids. We demonstrate three key findings. First, intraspecific microbiota variation is consistently less than interspecific microbiota variation, and microbiota-based models predict host species origin with high accuracy across the dataset. Interestingly, the age of host clade divergence positively associates with the degree of microbial community distinguishability between species within the host clades, spanning recent host speciation events (~1 million y ago) to more distantly related host genera (~108 million y ago). Second, topological congruence analyses of each group's complete phylogeny and microbiota dendrogram reveal significant degrees of phylosymbiosis, irrespective of host clade age or taxonomy. Third, consistent with selection on host-microbiota interactions driving phylosymbiosis, there are survival and performance reductions when interspecific microbiota transplants are conducted between closely related and divergent host species pairs. Overall, these findings indicate that the composition and functional effects of an animal's microbial community can be closely allied with host evolution, even across wide-ranging timescales and diverse animal systems reared under controlled conditions.

PMID:
27861590
PMCID:
PMC5115861
DOI:
10.1371/journal.pbio.2000225
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Public Library of Science Icon for PubMed Central
Loading ...
Support Center