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Med Sci Sports Exerc. 2017 Apr;49(4):661-668. doi: 10.1249/MSS.0000000000001143.

Thermodilution-determined Internal Jugular Venous Flow.

Author information

1
1Zurich Center of Integrative Human Physiology, University of Zurich, SWITZERLAND; 2Institute of Human Movement Sciences and Sport, ETH Zurich, SWITZERLAND; 3Medical Intensive Care Unit, University Hospital of Zurich, SWITZERLAND; 4Department of Anesthesia, The Copenhagen Muscle Research Center, Rigshospitalet, University of Copenhagen, DENMARK; 5Department of Biomedical Engineering, Toyo University, Tokyo, JAPAN; and 6Research Institute of Physical Fitness, Japan Women's College of Physical Education, Tokyo, JAPAN.

Abstract

PURPOSE:

Cerebral blood flow (CBF) increases ~20% during whole body exercise although a Kety-Schmidt-determined CBF is reported to remain stable; a discrepancy that could reflect evaluation of arterial vs. internal jugular venous (IJV) flow and/or that CBF is influenced by posture. Here we test the hypothesis that IJV flow, as determined by retrograde thermodilution increases during exercise when body position is maintained.

METHODS:

Introducing retrograde thermodilution, IJV flow was measured in eight healthy humans at supine and upright rest and during exercise in normoxia and hypoxia with results compared with changes in ultrasound-derived IJV flow and middle cerebral artery mean velocity (MCA Vmean).

RESULTS:

Thermodilution determined IJV flow was in reasonable agreement with values established in a phantom (R = 0.59, P < 0.0001) and correlated to the ultrasound-derived IJV flow (n = 7; Kendall τ, 0.28; P = 0.036). When subjects stood up, IJV blood flow decreased by 9% ± 13% (mean ± SD) (219 ± 57 to 191 ± 73 mL·min; P < 0.0001) and the influence of body position was maintained during exercise (P < 0.0001). Exercise increased both IJV flow and MCA Vmean (P = 0.019 and P = 0.012, respectively) and the two responses were similar (P = 0.50). During hypoxia, however, only MCA Vmean responded with a further increase (P < 0.0001).

CONCLUSIONS:

As determined by retrograde thermodilution, IJV flow seems little sensitive to hypoxia, but does demonstrate the about 15% reduction in CBF when humans are upright and, provided that body position is maintained, also the increase in CBF during whole body exercise.

PMID:
27861273
DOI:
10.1249/MSS.0000000000001143
[Indexed for MEDLINE]
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