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Pediatr Diabetes. 2017 Nov;18(7):619-621. doi: 10.1111/pedi.12472. Epub 2016 Nov 17.

Race or vitamin D: A determinant of intima media thickness in obese adolescents?

Author information

1
Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX.
2
Division of Pediatric Diabetes, Endocrinology, and Metabolism, Texas Children's Hospital, Baylor College of Medicine, Houston, TX.
3
Weight Management and Wellness Center, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.
4
Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.

Abstract

OBJECTIVE:

Carotid intima media thickness (IMT), a predictor of cardiovascular events, is reported to be higher in African-American (AA) vs White (AW) individuals. We investigated whether racial differences in IMT in obese adolescents could be explained by differences in 25 hydroxy-vitamin D [25(OH)D].

RESEARCH DESIGN AND METHODS:

A total of 63 obese adolescents had 25(OH)D levels, determination of IMT, body composition, insulin sensitivity (IS) by hyperinsulinemic-euglycemic clamp, lipids and blood pressure (BP).

RESULTS:

IMT was higher and 25(OH)D lower in AA vs AW. IMT correlated with 25(OH)D level (r = -0.38, P = .002) but not with IS. In multiple regression analysis, race, HbA1c, BP and age, and not 25(OH)D, BMI or IS, were the significant determinants of IMT (R2 = 0.44, P < .001). Without race in the model, 25(OH)D (β = -0.36, P = .009) contributed to the variance in IMT (R2 = 0.32, P = .007).

CONCLUSION:

Obese AA adolescents vs AW, have higher IMT, explained by race, BP, and HbA1c. Although 25(OH)D levels contribute to the variance in IMT, the observed racial difference in IMT could be mediated through other unknown race-related factors besides 25(OH)D.

KEYWORDS:

insulin sensitivity; intima media thickness; racial differences; vitamin D

PMID:
27860112
DOI:
10.1111/pedi.12472
[Indexed for MEDLINE]

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