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Stem Cells. 2017 Jun;35(6):1647-1648. doi: 10.1002/stem.2532. Epub 2016 Nov 22.

Adenosine Producing Mesenchymal Stem Cells.

Author information

1
Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Ulm University Medical Center, Ulm, Germany.
2
Department of Oto-Rhino-Laryngology, Head and Neck Surgery, University of Duisburg-Essen, Essen, Germany.

Abstract

Recent findings support the importance of the adenosine pathway in human immunology. Tissue specific differences exist with respect to the capacity of mesenchymal stem cells (MSC) to produce immune regulatory ATP metabolites. While some MSC may produce adenosine in a cell-autonomous fashion, other types of MSC require the cooperative activity of T-cells. Stem Cells 2017;35:1647-1648.

KEYWORDS:

Adenosine; Head and neck cancer; Mesenchymal stem cells; Microenvironment; Treg; Tumor

PMID:
27859896
DOI:
10.1002/stem.2532
[Indexed for MEDLINE]
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