Send to

Choose Destination
See comment in PubMed Commons below
J Clin Psychiatry. 1989 Jun;50(6):226-7.

Increased plasma tricyclic antidepressant concentrations in two patients concurrently treated with fluoxetine.

Author information

  • 1Department of Psychiatry, University of Tennessee, Memphis College of Medicine, TN 38105.


Two patients taking stable doses of standard tricyclic antidepressants were additionally treated with fluoxetine as the first step in a transition to that drug. After fluoxetine was added, both patients' plasma tricyclic antidepressant levels increased substantially. Adverse side effects occurred in one patient. Fluoxetine may increase the plasma levels of standard tricyclic antidepressants and the likelihood of tricyclic antidepressant toxicity.

Comment in

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk