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Adv Mater. 2017 Jan;29(3). doi: 10.1002/adma.201604630. Epub 2016 Nov 17.

Rapid Continuous Multimaterial Extrusion Bioprinting.

Liu W1,2,3, Zhang YS1,2,4, Heinrich MA1,2,5, De Ferrari F1,2,6, Jang HL1,2, Bakht SM1,2,7, Alvarez MM1,2,8,9, Yang J1,2,10, Li YC1,2, Trujillo-de Santiago G1,2,8,9, Miri AK1,2, Zhu K1,2,11,12, Khoshakhlagh P1,2,4, Prakash G1,2, Cheng H1,2, Guan X1,2, Zhong Z1,2, Ju J1,2, Zhu GH1,2,13, Jin X3, Shin SR1,2,4, Dokmeci MR1,2,4, Khademhosseini A1,2,4,14,15.

Author information

1
Biomaterials Innovation Research Center, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
2
Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
3
Key Laboratory of Textile Science and Technology, College of Textiles, Donghua University, Shanghai, 201620, China.
4
Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.
5
MIRA Institute of Biomedical Technology and Technical Medicine, Department of Developmental BioEngineering, University of Twente, Enschede, 7500AE, The Netherlands.
6
Department of Electronics and Telecommunications, Politecnico di Torino, Torino, 10129, Italy.
7
COMSATS Institute of Information and Technology, Islamabad, 45550, Pakistan.
8
Microsystems Technologies Laboratories, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
9
Centro de Biotecnología-FEMSA, Tecnológico de Monterrey at Monterrey, Monterrey, Nuevo León, CP, 64849, Mexico.
10
School of Mechanical and Chemical Engineering, University of Western Australia, Perth, WA, 6009, Australia.
11
Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, P. R. China.
12
Shanghai Institute of Cardiovascular Disease, Shanghai, 200032, P. R. China.
13
Department of Polymer Engineering, University of Akron, Akron, OH, 44325-0301, USA.
14
Department of Bioindustrial Technologies, College of Animal Bioscience and Technology, Konkuk University, Seoul, 143-701, Republic of Korea.
15
Department of Physics, King Abdulaziz University, Jeddah, 21569, Saudi Arabia.

Abstract

The development of a multimaterial extrusion bioprinting platform is reported. This platform is capable of depositing multiple coded bioinks in a continuous manner with fast and smooth switching among different reservoirs for rapid fabrication of complex constructs, through digitally controlled extrusion of bioinks from a single printhead consisting of bundled capillaries synergized with programmed movement of the motorized stage.

KEYWORDS:

bioinks; bioprinting; hydrogels; multimaterial; tissue engineering

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