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Muscle Nerve. 2017 Jul;56(1):160-162. doi: 10.1002/mus.25476. Epub 2016 Nov 28.

Peripheral nerve ultrasound in cerebellar ataxia neuropathy vestibular areflexia syndrome (CANVAS).

Author information

1
Department of Neurology and Clinical Neurophysiology, Bay of Plenty District Health Board, Tauranga, 3143, New Zealand.
2
Capital and Coast District Health Board, Wellington, New Zealand.
3
Auckland District Health Board, Auckland, New Zealand.

Abstract

INTRODUCTION:

We report preliminary findings of nerve ultrasound in patients with cerebellar ataxia neuropathy vestibular areflexia syndrome (CANVAS) who have sensory impairment due to dorsal root ganglionopathy.

METHODS:

The ultrasound cross-sectional area (CSA) of median and ulnar nerves of 7 CANVAS patients was compared with 7 age- and gender-matched controls and with the mean CSA of our reference population.

RESULTS:

The nerve CSA of CANVAS patients was significantly smaller than that of controls at all sites (P < 0.01). All but 1 individual measurement of CSA at the mid-forearm level in the CANVAS patients fell outside the normal control range and was >2 standard deviations below the reference mean.

CONCLUSIONS:

The small nerves in CANVAS probably reflect nerve thinning from axonal loss secondary to ganglion cell loss. Our data show a role for ultrasound in the diagnosis of CANVAS ganglionopathy. This may also be applicable to ganglionopathy from other causes. Muscle Nerve 56: 160-162, 2017.

KEYWORDS:

CANVAS; cross-sectional area; ganglionopathy; nerve ultrasound; peripheral nerves; sensory neuropathy

PMID:
27859440
DOI:
10.1002/mus.25476
[Indexed for MEDLINE]

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