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Hypertens Pregnancy. 2017 Feb;36(1):53-58. doi: 10.1080/10641955.2016.1237643. Epub 2016 Nov 18.

Vascular ultrasound measures before pregnancy and pregnancy complications: A prospective cohort study.

Author information

1
a Department of Epidemiology , Tulane University School of Public Health , New Orleans , Louisiana , USA.
2
b Department of Medicine, University of Turku and Division of Medicine , Turku University Hospital , Turku , Finland.
3
c Murdoch Childrens Research Institute , Parkville , Victoria , Australia.
4
d Department of Clinical Psychology , Tampere University Hospital and University of Tampere , Tampere , Finland.
5
e The Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Department of Clinical Physiology , Turku University Hospital , Turku , Finland.

Abstract

OBJECTIVES:

To examine the relationship between pre-pregnancy indicators of cardiovascular risk and pregnancy complications and outcomes.

STUDY DESIGN:

Data from 359 female participants in the Cardiovascular Risk in Young Finns Study were linked with the national birth registry. Flow-mediated dilatation (FMD; maximum change in the left brachial artery diameter after rest and hyperemia); carotid intima-media thickness (IMT); Young's elastic modulus (YEM); and carotid artery distensibility (Cdist) at the visit prior to the pregnancy were examined as predictors of hypertensive disorders, birthweight, and gestational age using multivariable linear regression with adjustment for confounders (age, BMI, smoking, and socioeconomic status).

RESULTS:

No relations were seen between FMD, IMT, or the stiffness indices, and hypertensive disorders. Higher pre-pregnancy FMD was associated with lower gestational age, while increased Cdist was associated with reduced birthweight-for-gestational-age.

CONCLUSIONS:

Some cardiovascular ultrasound measures of pre-pregnancy may predict pregnancy complications, but the association is likely to be small.

KEYWORDS:

Birth; brachial artery; hypertension; infant; low birth weight; pregnancy-induced; premature; ultrasonography

PMID:
27858505
PMCID:
PMC5580333
DOI:
10.1080/10641955.2016.1237643
[Indexed for MEDLINE]
Free PMC Article

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