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Neurosci Res. 2017 Feb;115:59-63. doi: 10.1016/j.neures.2016.11.002. Epub 2016 Nov 14.

Infection and inflammation in schizophrenia and bipolar disorder.

Author information

1
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
2
Department of Mental Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21287, USA.
3
Stanley Laboratory of Developmental Neurovirology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
4
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Stanley Laboratory of Developmental Neurovirology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
5
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Department of Mental Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21287, USA. Electronic address: asawa1@jhmi.edu.
6
Department of Mental Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21287, USA. Electronic address: weaton1@jhu.edu.

Abstract

The present study investigated the relationship between exposure to infectious agents and inflammation markers in individuals with schizophrenia (SZ), bipolar disorder (BP), and controls without a psychiatric disorder. We measured plasma levels of antibodies and innate immune markers and correlated them with clinical symptoms and cognitive function. In both SZ and BP, we found an increase in soluble CD14, and in BP an increase in C-reactive protein, IgM class antibodies against cytomegalovirus (CMV), and IgG class antibodies against herpes simplex virus 2. Furthermore in BP, we observed a negative relationship between IgG antibodies against CMV and scores for cognitive function.

KEYWORDS:

Antibody level; Bipolar disorder; Inflammation; Neurocognition; Schizophrenia

PMID:
27856235
DOI:
10.1016/j.neures.2016.11.002
[Indexed for MEDLINE]

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