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Am J Geriatr Psychiatry. 2017 Jan;25(1):64-72. doi: 10.1016/j.jagp.2016.08.018. Epub 2016 Aug 31.

Enhanced Molecular Aging in Late-Life Depression: the Senescent-Associated Secretory Phenotype.

Author information

1
Department of Psychiatry & Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, TX. Electronic address: brenosatler@gmail.com.
2
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA.
3
Departments of Psychiatry and of Pharmacology and Toxicology, Campbell Family Mental Health Research Institute of CAMH, University of Toronto, Toronto, Ontario, Canada.
4
Department of Statistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA.

Abstract

OBJECTIVE:

This study aims to investigate whether a systemic molecular pattern associated with aging (senescent-associated secretory phenotype [SASP]) is elevated in adults with late-life depression (LLD), compared with never-depressed elderly comparison participants.

DESIGN:

Cross-sectional study.

PARTICIPANTS:

We included 111 older adults (80 with LLD and 31 comparison participants) in this study.

MEASUREMENT:

A panel of 22 SASP-related proteins was extracted from a previous multiplex protein panel performed in these participants. We conducted a principal component analysis to create the SASP index based on individual weights of each of protein.

RESULTS:

Participants with LLD showed a significantly increased SASP index compared with comparison participants, after controlling for age, depressive symptoms, medical comorbidity (CIRS-G) scores, sex, and cognitive performance (F(1,98) = 7.3, p = 0.008). Correlation analyses revealed that the SASP index was positively correlated with age (r = 0.2, p = 0.03) and CIRS score (r = 0.27, p = 0.005), and negatively correlated with information processing speed (r = -0.34, p = 0.001), executive function (r = -0.27, p = 0.004) and global cognitive performance (r = -0.28, p = 0.007).

CONCLUSIONS:

To the best of our knowledge, this is the first study to show that a set of proteins (i.e., SASP index) primarily associated with cellular aging is abnormally regulated and elevated in LLD. These results suggest that individuals with LLD display enhanced aging-related molecular patterns that are associated with higher medical comorbidity and worse cognitive function. Finally, we provide a set of proteins that can serve as potential therapeutic targets and biomarkers to monitor the effects of therapeutic or preventative interventions in LLD.

KEYWORDS:

aging; cognitive performance; late-life depression; senescent associated secretory phenotype

PMID:
27856124
PMCID:
PMC5164865
DOI:
10.1016/j.jagp.2016.08.018
[Indexed for MEDLINE]
Free PMC Article

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