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Curr Med Chem. 2017;24(9):888-897. doi: 10.2174/0929867324666161117155325.

Vitamin D and the Epigenetic Machinery in Colon Cancer.

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1
Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77030. United States.

Abstract

Vitamin D is an important hormone that regulates many physiological processes related to human health. Through its nuclear receptor, VDR, vitamin D controls gene expression through genetic and epigenetic mechanisms. Increasing data have demonstrated the anti-cancer activities of vitamin D in various cancers, including colon cancer. This review summarizes the recent progresses in our understanding of the molecular mechanisms of vitamin D and its interaction with the epigenetic machinery in colon cancer. Vitamin D changes the status of DNA methylation and histone modifications, resulting in the activation of tumor suppressors and inhibition of oncogenes. In addition, vitamin D activates the expression of tumor suppressing miRNAs, which contribute to the tumor suppressive activity. Further understanding of the epigenetic action of vitamin D will help the development of therapeutic strategies targeting the vitamin D signaling pathway without inducing the hypercalcemic side effects.

KEYWORDS:

DNA methylation; Vitamin D; chemotherapy; epigenetics; histone methylation; microRNA

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