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Antimicrob Agents Chemother. 2017 Jan 24;61(2). pii: e01444-16. doi: 10.1128/AAC.01444-16. Print 2017 Feb.

Emergence of Colistin Resistance Gene mcr-1 in Cronobacter sakazakii Producing NDM-9 and in Escherichia coli from the Same Animal.

Author information

1
College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, China liubaotao-1986@163.com hush@qau.edu.cn.
2
Qingdao Academy of Agricultural Sciences, Qingdao, China.
3
College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, China.
4
College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, China.

Abstract

We report the presence of mcr-1 in Escherichia coli and carbapenem-resistant Cronobacter sakazakii from the same diseased chicken. The mcr-1 gene linked with ISApl1 was located on two different IncI2 plasmids, including one multidrug plasmid in E. coli, whereas fosA3-blaNDM-9 was on an IncB/O plasmid in C. sakazakii The development of the fosA3-blaNDM-9 resistance region was mediated by IS26 The colocation of mcr-1 or blaNDM-9 with other resistance genes will accelerate the dissemination of the two genes.

KEYWORDS:

Cronobacter sakazakii; NDM-9; chicken; insertion sequences; mcr-1

PMID:
27855074
PMCID:
PMC5278688
DOI:
10.1128/AAC.01444-16
[Indexed for MEDLINE]
Free PMC Article

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