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Am J Physiol Renal Physiol. 2017 Feb 1;312(2):F259-F265. doi: 10.1152/ajprenal.00550.2016. Epub 2016 Nov 16.

The critical role of Krüppel-like factors in kidney disease.

Author information

1
Division of Nephrology, Department of Medicine, Stony Brook University School of Medicine, New York, New York; sandeep.mallipattu@stonybrookmedicine.edu.
2
Division of Nephrology, Department of Medicine, Stony Brook University School of Medicine, New York, New York.
3
Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; and.
4
Renal Section, James J. Peters Veterans Affairs Medical Center, New York, New York.

Abstract

Krüppel-like factors (KLFs) are a family of zinc-finger transcription factors critical to mammalian embryonic development, regeneration, and human disease. There is emerging evidence that KLFs play a vital role in key physiological processes in the kidney, ranging from maintenance of glomerular filtration barrier to tubulointerstitial inflammation to progression of kidney fibrosis. Seventeen members of the KLF family have been identified, and several have been well characterized in the kidney. Although they may share some overlap in their downstream targets, their structure and function remain distinct. This review highlights our current knowledge of KLFs in the kidney, which includes their pattern of expression and their function in regulating key biological processes. We will also critically examine the currently available literature on KLFs in the kidney and offer some key areas in need of further investigation.

KEYWORDS:

Krüppel-like factors; differentiation; endothelial cells; fibrosis; glomerular disease; inflammation

PMID:
27852611
PMCID:
PMC5336586
DOI:
10.1152/ajprenal.00550.2016
[Indexed for MEDLINE]
Free PMC Article

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