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Mol Cancer. 2016 Nov 16;15(1):71.

Caveolin-1 in the regulation of cell metabolism: a cancer perspective.

Author information

1
Department of Medicine II, Medical Faculty Mannheim, University of Heidelberg, Mannheim, 68167, Germany.
2
Molecular Hepatology Section, Medical Faculty Mannheim, University of Heidelberg, Mannheim, 68167, Germany.
3
Department of Medicine II, Medical Faculty Mannheim, University of Heidelberg, Mannheim, 68167, Germany. christoph.meyer@medma.uni-heidelberg.de.
4
Molecular Hepatology Section, Medical Faculty Mannheim, University of Heidelberg, Mannheim, 68167, Germany. christoph.meyer@medma.uni-heidelberg.de.

Abstract

Caveolin-1 (CAV1) is an oncogenic membrane protein associated with endocytosis, extracellular matrix organisation, cholesterol distribution, cell migration and signaling. Recent studies reveal that CAV1 is involved in metabolic alterations - a critical strategy adopted by cancer cells to their survival advantage. Consequently, research findings suggest that CAV1, which is altered in several cancer types, influences tumour development or progression by controlling metabolism. Understanding the molecular interplay between CAV1 and metabolism could help uncover druggable metabolic targets or pathways of clinical relevance in cancer therapy. Here we review from a cancer perspective, the findings that CAV1 modulates cell metabolism with a focus on glycolysis, mitochondrial bioenergetics, glutaminolysis, fatty acid metabolism, and autophagy.

KEYWORDS:

Autophagy; CAV1; Fatty acid metabolism; Glutaminolysis; Glycolysis; Metabolic targets; Mitochondrion

PMID:
27852311
PMCID:
PMC5112640
DOI:
10.1186/s12943-016-0558-7
[Indexed for MEDLINE]
Free PMC Article

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