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Nutr J. 2016 Nov 16;15(1):98.

Fish consumption and risk of stroke: a second prospective case-control study from northern Sweden.

Author information

1
Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, 901 87, Umeå, Sweden. maria.wennberg@umu.se.
2
Department of Public Health and Clinical Medicine, Research Unit Skellefteå, Umeå University, Umeå, Sweden.
3
Department of Public Health and Clinical Medicine, Epidemiology and Global Health, Umeå University, Umeå, Sweden.
4
Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden.
5
Health Metrics Unit, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
6
Department of Public Health and Clinical Medicine, Medicine, Umeå University, Umeå, Sweden.
7
Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, Umeå University, Umeå, Sweden.
8
Department of Biobank Research, Umeå University, Umeå, Sweden.

Abstract

BACKGROUND:

Fish consumption has been concluded to be associated with decreased risk of stroke in several reviews. However, among men, but not women, an increased risk of stroke was previously found at high fish consumption (>3 meals/week) in northern Sweden. This study investigates if previous results on elevated stroke risk with high fish consumption in men in northern Sweden can be confirmed in a larger study with new cases in the same population.

METHODS:

A prospective nested case-control study was performed within the population-based Northern Sweden Health and Disease Study cohort. Information on fish consumption, other lifestyle and medical data was collected at baseline. Incident stroke cases (1987-2007, n = 735) were identified and 2698 controls matched for gender, age, year of baseline and geographical region.

RESULTS:

There were no associations between total fish or fatty fish consumption and stroke risk; thus the previous finding of increased risk of stroke with high fish consumption in men could not be repeated. High intake of lean fish (>twice/week compared to < once/month) was associated with increased stroke risk in men [OR 1.80 (95% CI 1.00, 3.21), but not in women [OR 0.50 (95% CI 0.24, 1.10)]. The association was driven by men living alone.

CONCLUSIONS:

The previous association between high total fish consumption and risk of stroke in men could not be repeated. The increased risk found in men with high intake of lean fish may be due to chance or confounding specific for this group.

KEYWORDS:

Confounding; Fish consumption; Hemorraghic stroke; Ischaemic stroke; Lifestyle

PMID:
27852254
PMCID:
PMC5112685
DOI:
10.1186/s12937-016-0216-3
[Indexed for MEDLINE]
Free PMC Article

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