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Reprod Toxicol. 2017 Jan;67:56-64. doi: 10.1016/j.reprotox.2016.11.009. Epub 2016 Nov 13.

Associations of urinary phthalate and phenol biomarkers with menarche in a multiethnic cohort of young girls.

Author information

1
Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place Box 1057, New York, NY 10029, USA. Electronic address: mary.wolff@mssm.edu.
2
Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place Box 1057, New York, NY 10029, USA. Electronic address: ashley.pajak7@mssm.edu.
3
Department of Environmental Health, Kettering Building, Room 208, University of Cincinnati College of Medicine, 3223 Eden Avenue, Cincinnati, OH 45267-0056, USA. Electronic address: pinneysm@ucmail.uc.edu.
4
Division of Environmental and Occupational Disease Control, California Department of Public Health, 850 Marina Bay Pkwy, Bldg P, Richmond, CA 94804, USA. Electronic address: gayle.windham@cdph.ca.gov.
5
Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place Box 1057, New York, NY 10029, USA. Electronic address: maida.galvez@mssm.edu.
6
Centers for Disease Control and Prevention, 4770 Buford Hwy, MS-F17, Atlanta, GA 30341, USA. Electronic address: szr8@cdc.gov.
7
Centers for Disease Control and Prevention, 4770 Buford Hwy, MS-F17, Atlanta, GA 30341, USA. Electronic address: zca2@cdc.gov.
8
Centers for Disease Control and Prevention, 4770 Buford Hwy, MS-F17, Atlanta, GA 30341, USA. Electronic address: xay5@cdc.gov.
9
Centers for Disease Control and Prevention, 4770 Buford Hwy, MS-F17, Atlanta, GA 30341, USA. Electronic address: aic7@cdc.gov.
10
Division of Research, Kaiser Permanente, 2000 Broadway, Oakland, CA 94612, USA. Electronic address: larry.kushi@kp.org.
11
Division of Adolescent Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue (ML-4000), Cincinnati, OH 45229-3029, USA. Electronic address: frank.biro@cchmc.org.
12
Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place Box 1057, New York, NY 10029, USA. Electronic address: susan.teitelbaum@mssm.edu.

Abstract

To study potential environmental influences on puberty in girls, we investigated urinary biomarkers in relation to age at menarche. Phenols and phthalates were measured at baseline (6-8 years of age). Menarche was ascertained over 11 years for 1051 girls with menarche and biomarkers. Hazards ratios were estimated from Cox models adjusted for race/ethnicity and caregiver education (aHR, 95% confidence intervals [CI] for 5th vs 1st quintile urinary biomarker concentrations). 2,5-Dichlorophenol was associated with earlier menarche (aHR 1.34 [1.06-1.71]); enterolactone was associated with later menarche (aHR 0.82 [0.66-1.03]), as was mono-3-carboxypropyl phthalate (MCPP) (aHR 0.73 [0.59-0.91]); the three p-trends were <0.05. Menarche differed by 4-7 months across this range. Enterolactone and MCPP associations were stronger in girls with below-median body mass index. These analytes were also associated with age at breast development in this cohort. Findings from this prospective study suggest that some childhood exposures are associated with pubertal timing.

KEYWORDS:

Environmental; Menarche; Phenols; Phthalates; Phytoestrogens

PMID:
27851993
PMCID:
PMC5303175
DOI:
10.1016/j.reprotox.2016.11.009
[Indexed for MEDLINE]
Free PMC Article

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