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Neurosci Lett. 2017 Jan 1;636:254-257. doi: 10.1016/j.neulet.2016.11.023. Epub 2016 Nov 13.

Cognitive ability in Down syndrome and its relationship to urinary neopterin, a marker of activated cellular immunity.

Author information

1
University College London, Division of Psychiatry, London, United Kingdom; Sheffield Teaching Hospitals NHS Trust, Department of Neurology, Sheffield, United Kingdom. Electronic address: takiszis@gmail.com.
2
University College London, Division of Psychiatry, London, United Kingdom; The LonDowns Consortium, United Kingdom.
3
Centre for Biomarker Research, School of Applied Sciences, University of Huddersfield, Huddersfield, United Kingdom.

Abstract

BACKGROUND:

Neopterin is an unconjugated pteridine that is secreted in large quantities by activated macrophages and can be used as a clinical marker of activated cellular immunity and oxidative stress. We aimed to investigate whether urinary neopterin levels are associated with cognitive function in people with Down syndrome (DS).

METHODS:

Out of 32 adults with DS who originally participated in a longitudinal study, 25 were followed up at 4 years. Informants rated their adaptive behavior (ABAS) and the adults with DS attempted assessments of language skills and memory at both baseline and follow-up time points (Modified Memory Object Task, MOMT), and receptive vocabulary (British Picture Vocabulary Scale, BPVS).

RESULTS:

Neopterin/creatinine levels were negatively correlated with change in the MOMT total score (Spearman's Rho=-0.517, p=0.020) and change in the MOMT delayed recall score (Spearman's Rho=-0.577, p=0.008) over time, i.e. higher neopterin/creatinine level was associated with worse performance on a test of cognitive ability over time.

CONCLUSION:

Urine neopterin may have potential as a biomarker for memory decline in Down syndrome, and could potentially also help to track progression of mild cognitive impairment (MCI) to Alzheimer's disease in other high risk populations.

KEYWORDS:

Aging; Alzheimer’s disease; Down syndrome; Memory; Neopterin; Oxidative stress

PMID:
27851899
PMCID:
PMC6455994
DOI:
10.1016/j.neulet.2016.11.023
[Indexed for MEDLINE]
Free PMC Article

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