Format

Send to

Choose Destination
Appl Physiol Nutr Metab. 2016 Dec;41(12):1225-1232. Epub 2016 Aug 5.

Acute cocoa flavanol improves cerebral oxygenation without enhancing executive function at rest or after exercise.

Author information

1
a Department of Human Physiology, Faculty of Physical Education and Physical Therapy, Vrije Universiteit Brussel, Brussels, Belgium.
2
b Department of Physical Activity, Muscle and Health, Faculty of Sport Science and Physical Education, Université de droit et de la santé Lille 2, France.
3
c Department of Physical Education, University of Minas Gerais, Belo Horizonte, Brazil.
4
d School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Queensland, Australia.

Abstract

Acute exercise-induced improvements in cognitive function are accompanied by increased (cerebral) blood flow and increased brain-derived neurotrophic factor (BDNF) levels. Acute cocoa flavanol (CF) intake may improve cognitive function, cerebral blood flow (in humans), and BNDF levels (in animals). This study investigated (i) the effect of CF intake in combination with exercise on cognitive function and (ii) cerebral hemodynamics and BDNF in response to CF intake and exercise. Twelve healthy men participated in this randomized, double-blind, crossover study. Participants performed a cognitive task (CT) at 100 min after acute 903-mg CF or placebo (PL) intake, followed by a 30-min time-trial. Immediately after this exercise, the same CT was performed. Prefrontal near-infrared spectroscopy was applied during CT and exercise to measure changes in oxygenated (ΔHbO2), deoxygenated (ΔHHb), and total haemoglobin (ΔHbtot) and blood samples were drawn and analyzed for BDNF. Reaction time was faster postexercise, but was not influenced by CF. ΔHbO2 during the resting CT was increased by CF, compared with PL. ΔHbO2, ΔHHb, and ΔHbtot increased in response to exercise without any effect of CF. During the postexercise cognitive task, there were no hemodynamic differences between CF or PL. Serum BDNF was increased by exercise, but was not influenced by CF. In conclusion, at rest, CF intake increased cerebral oxygenation, but not BDNF concentrations, and no impact on executive function was detected. This beneficial effect of CF on cerebral oxygenation at rest was overruled by the strong exercise-induced increases in cerebral perfusion and oxygenation.

KEYWORDS:

BDNF; NIRS; cerebral hemodynamics; cocoa flavanol; cognition; exercice physique; exercise; flavanols de cacao; hémodynamique cérébrale

PMID:
27849355
DOI:
10.1139/apnm-2016-0245
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center