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Platelets. 2017 May;28(3):301-304. doi: 10.1080/09537104.2016.1237627. Epub 2016 Nov 16.

Decreased levels of platelet-derived soluble glycoprotein VI detected prior to the first diagnosis of coronary artery disease in HIV-positive individuals.

Author information

1
a Department of Infectious Diseases , The Alfred Hospital and Monash University , Melbourne , Australia.
2
b Department of Cancer Biology and Therapeutics , Australian National University , Canberra , Australia.
3
c Australian Centre for Blood Diseases , Monash University , Melbourne , Australia.
4
d Centre for Biomedical Research , Burnet Institute , Melbourne , Australia.
5
e Immunology Section, Basic Medical Sciences Department, Faculty of Medicine , Hashemite University , Zarqa , Jordan.

Abstract

HIV-positive patients are at increased risk for coronary artery disease (CAD); changes in platelet activation may play a role. This study was performed to determine if levels of soluble glycoprotein VI (sGPVI), a platelet-specific marker of activation, were different in HIV-positive patients compared with HIV-negative controls and further if levels were predictive of CAD in HIV. Twenty-four HIV-positive individuals (HIV cases) with CAD were compared with 46 age- and sex-matched HIV-positive controls without CAD and 41 HIV-negative controls (healthy controls). Platelet activation (represented by sGPVI level) was compared 12 months and 1 month prior to CAD diagnosis. sGPVI was quantified by ELISA. sGPVI levels were higher in HIV-positive subjects (combined) than healthy controls (122.5 ng/mL [interquartile ranges (IQR) 90.3-160.5] versus 84.7 ng/mL [IQR 48.6-119.5], p <0.001). Twelve months before the event, there was no difference in sGPVI between HIV cases and HIV controls (113.4 ng/mL [IQR 85.6-141.65] versus 128.0 ng/mL [IQR 96.6-179.4], p = 0.369). One month prior to the event, sGPVI was significantly lower in HIV cases compared with HIV controls (109.0 ng/mL [IQR 79.4-123.4] versus 133.9 ng/mL [IQR 112.7-171.9], p = 0.010). These results remained significant following adjustment for possible confounders. This work demonstrates that HIV infection is associated with higher sGPVI levels. A fall in sGPVI immediately prior to first coronary artery event may reflect a loss of negative-feedback mechanism and be an important pathological step in the development of symptomatic CAD, but further work is needed to confirm these findings and determine their clinical impact.

KEYWORDS:

Cardiovascular disease; HIV; Thrombosis; soluble glycoprotein VI

PMID:
27848272
DOI:
10.1080/09537104.2016.1237627
[Indexed for MEDLINE]

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