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Neurol Sci. 2017 Jan;38(1):41-51. doi: 10.1007/s10072-016-2764-x. Epub 2016 Nov 15.

Advanced magnetic resonance imaging of neurodegenerative diseases.

Author information

1
Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina, 60, 20132, Milan, Italy.
2
Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina, 60, 20132, Milan, Italy. filippi.massimo@hsr.it.
3
Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy. filippi.massimo@hsr.it.

Abstract

Magnetic resonance imaging (MRI) is playing an increasingly important role in the study of neurodegenerative diseases, delineating the structural and functional alterations determined by these conditions. Advanced MRI techniques are of special interest for their potential to characterize the signature of each neurodegenerative condition and aid both the diagnostic process and the monitoring of disease progression. This aspect will become crucial when disease-modifying (personalized) therapies will be established. MRI techniques are very diverse and go from the visual inspection of MRI scans to more complex approaches, such as manual and automatic volume measurements, diffusion tensor MRI, and functional MRI. All these techniques allow us to investigate the different features of neurodegeneration. In this review, we summarize the most recent advances concerning the use of MRI in some of the most important neurodegenerative conditions, putting an emphasis on the advanced techniques.

KEYWORDS:

Alzheimer’s disease; Atrophy; Dementia with Lewy bodies; Diffusion tensor MRI; Frontotemporal dementia; Magnetic resonance imaging; Parkinson’s disease; Primary progressive aphasia; Resting state functional MRI

PMID:
27848119
DOI:
10.1007/s10072-016-2764-x
[Indexed for MEDLINE]

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