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Biomed Pharmacother. 2016 Dec;84:1776-1782. doi: 10.1016/j.biopha.2016.10.104. Epub 2016 Nov 12.

Triptolide inhibits the migration and invasion of human prostate cancer cells via Caveolin-1/CD147/MMPs pathway.

Author information

1
Department of Biochemistry, Dalian Medical University, 9 South Lvshun Road Western Section, Dalian 116044, Liaoning, China.
2
School of Life Science and Medicine, Dalian University of Technology, Panjin 124221, Liaoning, China.
3
Department of Urology, First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning, China.
4
Department of Urology, First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning, China. Electronic address: yangdeyong@dmu.edu.cn.
5
Department of Biochemistry, Dalian Medical University, 9 South Lvshun Road Western Section, Dalian 116044, Liaoning, China. Electronic address: wangshujing@dmu.edu.cn.

Abstract

Prostate cancer (PCa) is the second most common type of carcinoma and the 5th leading cause of cancer-related death in males. Triptolide, is a main and effective component of Tripterygium wilfordii Hook F, which exerts an broad-spectrum anti-malignant tumor function. However, the effect of triptolide on migration and invasion of human prostate cancer cells is still poorly understood. In this study, we demonstrated that triptolide significantly inhibited the proliferation, migration and invasion of prostate cancer cells in a time- and dose-dependent manner. Caveolin-1 (Cav-1) is regarded as a major structural protein of caveolae and participated in lipid transport, signal transduction and tumor progression. Triptolide treatment inhibited the expression of tumor promoter Cav-1 and reduced CD147 and MMPs activities at both mRNA and protein levels. Meanwhile, triptolide treatment combined with Cav-1 knockdown in PCa cells enhanced the effects of anti-migration and anti-invasion, and those effects were restored following Cav-1-rescued. Together, our research indicates that triptolide represses the migration and invasion through Cav-1/CD147/MMPs pathway in PCa cells, which gives a better understanding of triptolide in clinical aggressive prostate cancer therapy.

KEYWORDS:

Invasion; Migration; Prostate cancer; Triptolide

PMID:
27847199
DOI:
10.1016/j.biopha.2016.10.104
[Indexed for MEDLINE]

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