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Clin Neurol Neurosurg. 2017 Jan;152:12-15. doi: 10.1016/j.clineuro.2016.11.005. Epub 2016 Nov 10.

Sensory-motor axonal polyneuropathy involving cranial nerves: An uncommon manifestation of disulfiram toxicity.

Author information

1
Neurology Department, Centro Hospitalar Vila Nova de Gaia/Espinho, Porto, Portugal. Electronic address: telma.cristiana.santos@gmail.com.
2
Neurology Department, Centro Hospitalar Vila Nova de Gaia/Espinho, Porto, Portugal.

Abstract

Disulfiram (tetraethylthiuram disulfide) has been used for the treatment of alcohol dependence. An axonal sensory-motor polyneuropathy with involvement of cranial pairs due to disulfiram is exceedingly rare. The authors report a unique case of an extremely severe axonal polyneuropathy involving cranial nerves that developed within weeks after a regular dosage of 500mg/day disulfiram. To the authors best knowledge, such a severe and rapidly-progressive course has never been described with disulfiram dosages of only 500mg/day.

KEYWORDS:

Alcohol; Disulfiram; Neuropathy

PMID:
27846399
DOI:
10.1016/j.clineuro.2016.11.005
[Indexed for MEDLINE]

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